Application of Amino-Functionalized SBA-15 Type Mesoporous Silica in One-Pot Synthesis of Spirooxindoles

Amino-functionalized SBA-15 (SBA-Pr-NH2) has been used as a new basic nanocatalyst in the one-pot synthesis of spirooxindole derivatives via the three-component condensation reaction of isatins, activated methylene reagents, and dimedone in an aqueous medium. SBA-Pr-NH2 has been established as an efficient heterogeneous nanoporous solid basic catalyst (pore size of 6 nm) that can be easily handled and removed from the reaction mixture by simple filtration, and also recovered and reused without any noticeable loss of reactivity.

Graphical abstractThe application of SBA-Pr-NH2 as a nanocatalyst for the one-pot three-component reaction of isatins with malononitrile or cyanoacetic esters and dimedone, for the synthesis of spirooxindole derivatives in an aqueous medium, has been reported.Figure optionsDownload full-size imageDownload as PowerPoint slide