| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5925092 | Physiology & Behavior | 2012 | 8 Pages |
The SHR Y chromosome has loci which are involved with behavioral, endocrine and brain phenotypes and respond to acute stress to a different degree than that of the WKY Y chromosome. The objectives were to determine if WKY males with an SHR Y chromosome (SHR/y) when compared to males with a WKY Y chromosome would have: 1. a greater increase in systolic and diastolic blood pressures (BP), heart rate (HR), and locomotor activity when placed in an open field environment and during an acute stress procedure; 2. enhanced stress hormone responses; 3. greater voluntary running; and 4. increased brain Sry expression. The SHR/y strain showed a significant rise in BP (32%) and HR (10%) during the open field test and exhibited higher BP (46% change) during air jet stress. SHR/y had higher locomotor activity and less immobility and had increased stress induced plasma norepinephrine and adrenocorticotrophic hormone and 3-4Â Ã more voluntary running compared to WKY. Differential Sry expression between WKY and SHR/y in amygdala and hippocampus was altered at rest and during acute stress more than that of WKY. Evidence suggests that this animal model allows novel functions of Y chromosome loci to be revealed. In conclusion, a transcription factor on the SHR Y chromosome, Sry, may be responsible for the cardiovascular, endocrine and behavioral phenotype differences between SHR/y and WKY males.
⺠This research is novel and contributes to the scientific field by determining a behavioral effect of a genetic cross which took 19 rat generations to develop of the Y chromosome from an spontaneously hypertensive rat backcrossed into a normotensive WKY autosomal background. ⺠We have published several papers describing the blood pressure effect of the SHR Y chromosome but are only beginning to understand how this Y chromosome affects behavior like reaction in the open field and cardiovascular responses, physiological stress responses, running activity and Sry expression in the brain.
