TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglion

Article ID	Journal	Published Year	Pages	File Type
5925095	Physiology & Behavior	2012	7 Pages	PDF

Abstract

âº TRPM2 currents and Ca2+ levels in glutathione depleted dorsal root ganglion (DRG) neuron were increased. âº N-acetylcysteine (NAC) supplementation modulated the values. âº The current study is the first to compare treatment with NAC to TRPM2 currents and Ca2+ influx in the DRG neurons.

Keywords

DRG Oxidative stress injury TRPM2 2-aminoethyl diphenylborinate NMDG+ADPR 2-APB N-methyl-d-glucamine Trp dorsal root ganglion ROS [Ca2+]i Glutathione depletion Intracellular Ca2+Pain Whole cell N-acetyl cysteine transient receptor potential Lipid peroxidation Reactive oxygen species