Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5925253 | Physiology & Behavior | 2011 | 7 Pages |
Abstract
⺠Maxipost and R-Maxipost act as +/â modulators on BK (KCa1.1) and Kv7.1 channels. ⺠Potassium channel dysfunction may underlie hyperactive CNS disorders and tinnitus. ⺠High doses of salicylate produced behavior consistent with the presence of tinnitus. ⺠Maxipost and R-Maxipost reversal of salicylate induced tinnitus is dose dependent. ⺠Maxipost and R-Maxipost may reduce tinnitus by modulating potassium channels.
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Authors
Edward Lobarinas, William Dalby-Brown, Daniel Stolzberg, Naheed R. Mirza, Brian L. Allman, Richard Salvi,