Simulated systemic recurrent Mycoplasma infection in rats induces recurrent sickness responses without residual impairment in spatial learning and memory

► Simulated recurrent Mycoplasma infection induced recurrent fever, lethargy, anorexia. ► Following recovery there was no stunting or residual impairment in learning/memory. ► Repetitive I.P. administration of FSL-1, 10 days apart, did not result in tolerance. ► We observed no residual histological damage to the hippocampus of rats.