| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5926164 | Respiratory Physiology & Neurobiology | 2013 | 4 Pages |
Abstract
⺠The effects of the phosphodiesterase-5 inhibitor Vardenafil in pulmonary arterial hypertension are unknown. ⺠We show for the first time that Vardenafil attenuates monocrotaline-induced pulmonary artery hypertension in rats. ⺠Vardenafil improves pulmonary vascular remodeling, hemodynamics, right ventricular hypertrophy and exercise capacity. ⺠Whether Vardenafil is a treatment option for patients with pulmonary hypertension needs to be elucidated.
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Authors
Stephan Schroll, Daniela Sebah, Michael Wagner, Viktoria Popara, Michael Pfeifer, Friedrich Blumberg,