Article ID Journal Published Year Pages File Type
5926250 Respiratory Physiology & Neurobiology 2013 6 Pages PDF
Abstract
► Tetrahydrobiopterin (BH4) increases lung NO production. ► BH4 inhibits hypoxic pulmonary vasoconstriction and the responsiveness of hypoxic rats to BH4 is lower than that of normoxic rats. ► NOS uncoupling due to BH4 oxidation plays a role in chronic hypoxia. ► Inducible NO synthase (iNOS) appears to be the main source of exhaled NO in rats.
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Life Sciences Biochemistry, Genetics and Molecular Biology Physiology
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Chronic hypoxia inhibits tetrahydrobiopterin-induced NO production in rat lungs
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