Article ID Journal Published Year Pages File Type
5926369 Respiratory Physiology & Neurobiology 2012 10 Pages PDF
Abstract

Baroreflex sensitivity (BRS) is reduced in humans during snoring, however the mechanisms are unknown. We used an anaesthetised rabbit induced snoring (IS) model, to test: (1) whether IS was associated with reduced BRS; and (2) if snoring related vibration transmission to peri-carotid tissues influenced BRS levels. BRS was quantified using the spontaneous sequence technique. During IS, BRS fell by 40%, without any associated change in blood pressure (BP) but accompanied by an increase in heart rate (HR). Direct application of a snore frequency and intensity matched vibratory stimulus to the peri-carotid tissues of non-snoring tracheostomised rabbits had no effect on BRS, HR or BP. In conclusion, IS induced depression of BRS is likely mediated via a HR driven change in BRS operating point that is unrelated to snoring-related vibration transmission to carotid baroreceptors. The anaesthetised IS rabbit provides a model in which mechanistic interactions between snoring and BRS can be further explored.

► BRS depression during snoring is likely mediated via heart rate driven change in baroreflex operating point. ► Snoring-related vibration transmission to the peri-carotid tissue is not associated with the snoring related reduction in BRS. ► The anaesthetised IS rabbit provides a model in which mechanistic interactions between snoring and BRS can be further explored.

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