Article ID Journal Published Year Pages File Type
5926384 Respiratory Physiology & Neurobiology 2012 10 Pages PDF
Abstract
► We examine the effects of human serum, bovine serum albumin, gamma globulin and cholesterol on dynamic and structural properties of surfactant. ► Serum modified aggregation state increases the inactive subtype, decreases the fluidity in the polar region and inactivates EPS. ► A serum component, different from albumin, gamma globulin and cholesterol, may be responsible for the loss of surfactant activity. ► There is a correlation between the fluidity in the polar region of the surfactant bilayer and the surface activity. ► Serum leads to increased structural rigidity in the polar area of the phospholipid bilayer, which compromises the surfactant performance.
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