Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5926384 | Respiratory Physiology & Neurobiology | 2012 | 10 Pages |
Abstract
⺠We examine the effects of human serum, bovine serum albumin, gamma globulin and cholesterol on dynamic and structural properties of surfactant. ⺠Serum modified aggregation state increases the inactive subtype, decreases the fluidity in the polar region and inactivates EPS. ⺠A serum component, different from albumin, gamma globulin and cholesterol, may be responsible for the loss of surfactant activity. ⺠There is a correlation between the fluidity in the polar region of the surfactant bilayer and the surface activity. ⺠Serum leads to increased structural rigidity in the polar area of the phospholipid bilayer, which compromises the surfactant performance.
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Authors
MarÃa MartÃnez Sarrasague, Alejandra Cimato, Emilio Rubin de Celis, Graciela Facorro,