5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia

Article ID	Journal	Published Year	Pages	File Type
5926429	Respiratory Physiology & Neurobiology	2011	5 Pages	PDF

Abstract

âº 5HT1A receptors do not alter excitatory neurotransmission to cardiac vagal neurons (CVNs) under control conditions. âº During recovery from Hypoxia/Hypercapnia an endogenous serotonergic pathway inhibits glutamatergic transmission to CVNs. âº A decrease in 5-HT1A activation would augment glutamate input to CVNs causing bradycardia in diseases such as SIDS and OSA.

Keywords

CVNs pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonic acid H/H PPADS Parasympathetic SIDS AP-5 RSA 6-Cyano-7-nitroquinoxaline-2,3-dione d-2-amino-5-phosphonovalerate EPSC Respiratory Sinus Arrhythmia Ambiguus Apnea excitatory post-synaptic current Serotonin CNQX Heart rate Cardiac nucleus ambiguus Hypercapnia Hypoxia