Amorphous Mesoporous Iron Aluminophosphate Catalyst for the Synthesis of 1,5-Benzodiazepines

A simple and versatile method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones in the presence of solvents and under solvent-free conditions that used an amorphous mesoporous iron aluminophosphate as catalyst was developed. High yields with excellent selectivity were obtained with a wide variety of ketones under mild reaction conditions. The catalyst had the advantages of ease of preparation, ease of handling, simple recovery, reusability, non toxicity, and being inexpensive.

Graphical abstractThe catalytic activity of amorphous iron aluminophosphates for the selective synthesis of 1,5-benzodiazepines via condensation reaction is attributed to the synergetic effect (Al, P, and Fe) and mesoporous nature of the material.Figure optionsDownload full-size imageDownload as PowerPoint slide