Recent advances in mechanistic studies on Ni catalyzed cross-coupling reactions

A variety of Ni catalyzed cross-coupling reactions have emerged as efficient new methods for the construction of C–C bonds, and many mechanistic studies have been conducted to understand the factors controlling the reactivity and selectivity of Ni catalyzed reactions. The mechanisms of Ni catalyzed reactions are often very different from the corresponding Pd catalyzed processes because radical or bimetallic pathways are frequently involved in Ni catalyzed cross-coupling reactions. This review summarized recent advances in the mechanism of Ni catalyzed cross-coupling reactions. These are important for the development of new Ni catalyzed cross-coupling reactions with improved efficiency and selectivity.

Graphical AbstractRecent advances in Ni catalyzed cross-coupling reactions including alkyl reagents, C-O activation, and C-H functionalization were reviewed. The mechanisms of Ni catalyzed reactions are usually different from the Pd catalyzed counterparts because radical and bimetallic intermediates are involved.Figure optionsDownload full-size imageDownload as PowerPoint slide