Vanadium catalyzed direct synthesis of imines from amines or alcohols and amines by an aerobic oxidative reaction under mild conditions

The direct synthesis of imines from amines or alcohols and amines by vanadium catalyzed aerobic oxidation was developed. Without an additive or promoter, various symmetrical and unsymmetrical imines were obtained in good to excellent yields under mild conditions with air as an environmentally benign oxidant. The catalyst is very easy to prepare and use, and this catalytic system is also effective for the synthesis of heteroatom-containing imines.

Graphical AbstractAn effective approach to the synthesis of symmetrical and unsymmetrical imines by vanadium catalyzed aerobic oxidative reactions of amines and alcohols with amines under mild conditions was developed.Figure optionsDownload full-size imageDownload as PowerPoint slide