| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 59338 | Chinese Journal of Catalysis | 2015 | 7 Pages |
Abstract
A new protocol that enables asymmetric hydroaminomethylation of styrenes to afford chiral amines has been developed. Catalysed by an Rh-phosphine species and a chiral phosphoric acid, styrenes are converted into β-chiral amines with good enantioselectivities under syngas in the presence of an amine and Hantzsch ester. The reaction involves two key steps, hydroformylation and reductive amination, with the former catalysed by the Rh species whilst the latter by the phosphoric acid.
Graphical AbstractCombining metal-catalysed hydroformylation with a chiral organo-acid-catalysed reductive amination allows for asymmetric hydroaminomethylation to be realised.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Barbara Villa-Marcos, Jianliang Xiao,