One-pot green synthesis of enamides and 1,3-diynes

A green organic synthetic method combining reductive acylation of ketoximes and oxidative coupling of terminal alkynes was developed. This novel process enables enamides and 1,3-diynes to be synthesized simultaneously in high yields and under mild conditions without the use of terminal reductants/oxidants.

Graphical AbstractAn oxidation was combined with a reduction in one pot, to give the two corresponding products, i.e., enamides and 1,3-diynes, simultaneously. This new process avoids the use of both terminal oxidants and terminal reductants.Figure optionsDownload full-size imageDownload as PowerPoint slide