| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5943116 | Atherosclerosis | 2016 | 11 Pages |
Abstract
Our results indicate a direct effect of glucocorticoids on macrophages braking atherosclerosis initiation, reducing pro-inflammatory markers and OxLDL uptake and cholesterol re-esterification, but also inhibiting cholesterol output. These effects appear to be mediated, at least in part, by 11βHSD1 activity.
Keywords
IL-6apoprotein E11βHSD2SRA1H6PDHIL-12BRibosomal protein L4Emr111β-Hydroxysteroid dehydrogenase 211β-Hydroxysteroid dehydrogenase type 211β-hydroxysteroid dehydrogenase type 111β-hydroxysteroid dehydrogenase 111βHSD1LXRαABCG1MMRTNFαACATABCA1PLA2CD163acyl-CoA:cholesterol acyltransferaseATP-binding cassette transporter A1FAT/CD36ATP-binding cassette transporter G1phospholipase A2fatty acid translocaseApo Einterleukin-6tumor necrosis factor αcluster of differentiation 163Foam cellsHexose-6-phosphate dehydrogenaseliver X receptor αcortisolcortisoneinterleukin-10 receptorMacrophage mannose receptor
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Authors
Angelo Ledda, Marina González, José Gulfo, Ivo DÃaz Ludovico, Nahuel Ramella, Juan Toledo, Horacio Garda, Mar Grasa, Montserrat Esteve,