Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5943190 | Atherosclerosis | 2016 | 9 Pages |
Abstract
First, our results demonstrate that myocardial ischemia is associated with downregulation and posttranslational modification of cardiac FoxO1. Second, we show in a mouse model of postischemic heart failure that posttranslational modulation of FoxO1 alters heart function involving collagen and protein metabolism. Therefore, posttranslational modifications of FoxO1 could be an option to target remodeling processes in postischemic heart failure.
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Authors
Ben Arpad Kappel, Robert Stöhr, Lorenzo De Angelis, Maria Mavilio, Rossella Menghini, Massimo Federici,