H3PW12O40 catalyzed synthesis of benzoxazine and quinazoline in aqueous media

A heteropolyacid efficiently catalyzed the cyclocondensation reaction of 2-aminobenzamide and salicylamide with aldehydes and ketones to afford good yields of benzoxazine and quinazoline ring systems in an aqueous medium. The method gives clean reactions, has simple workup procedure, and uses environment friendly conditions.

Graphical AbstractH3PW12O40 was used as an efficient catalyst for the preparation of benzoxazine and quinazoline ring systems in aqueous media. Advantages include high yields, short reaction times, easy work-up, and green procedure.Figure optionsDownload full-size imageDownload as PowerPoint slide