Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5945391 | Atherosclerosis | 2014 | 5 Pages |
Abstract
Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.
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Authors
Rehan Malik, Ehimen C. Aneni, Lara Roberson, Oluseye Ogunmoroti, Shozab S. Ali, Sameer Shaharyar, Adnan Younus, Omar Jamal, Muhammad A. Aziz, Seth S. Martin, Michael J. Blaha, Theodore Feldman, Arthur S. Agatston, Emir Veledar, Khurram Nasir,