Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5946073 | Atherosclerosis | 2014 | 53 Pages |
Abstract
Our study revealed an unexpected off-target effect of CETP inhibitors that reduce the mature form of SREBP2, leading to attenuated transcription of hepatic LDLR and PCSK9. This negative regulation of SREBP pathway by ANA manifested in mice where CETP activity was absent and affected serum cholesterol metabolism.
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Authors
Bin Dong, Amar Bahadur Singh, Chin Fung, Kelvin Kan, Jingwen Liu,