| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5947419 | Atherosclerosis | 2013 | 5 Pages |
â¢Increased C-IMT could be observed in young subjects with low risk for CVDâ¢High C-IMT, within normal range, is associated with peripheral insulin resistanceâ¢C-IMT closed to the upper normal limit is associated with hepatic insulin resistanceâ¢C-IMT closed to the upper normal limit is associated with b-cell dysfunctionâ¢Monitoring C-IMT measurement should become a routine exam even in young subjects
BackgroundCarotid Intima-Media Thickness (C-IMT) is a reliable predictor of cardiovascular events. We examined if increased C-IMT was associated with defects in glucose metabolism in non-diabetic subjects independently of age.MethodsIn 366 Caucasian non-diabetic subjects of the CARAMERIS study, we measured glucose response during a 75 g-Oral Glucose Tolerance Test (OGTT), insulin sensitivity index (ISI, by Matsuda Index), Liver Insulin Resistance Index (Liver-IR), insulin secretion by ÎAUC Ins0-120/Glu0-120 (ÎI/ÎG) and beta cell function (Disposition Index, DI).ResultsSubjects were divided in two groups according to the median age (AGE1 â¤Â 45 y; AGE2 > 45 y). Only 5 subjects in AGE1 and 32 in AGE2 had C-IMT > 0.9 mm. Compared to AGE1, AGE2 had a worse cardio-metabolic profile, increased cholesterol, glucose and insulin concentrations, blood pressure and C-IMT. Both ÎI/ÎG ratio and DI were significantly reduced in AGE2. By considering tertiles of C-IMT in each AGE group (G1-G3, where G3 comprised the highest C-IMT), we found that G3 showed increased OGTT glucose profiles and Liver IR, decreased ISI and DI, compared to G1 in each AGE group.ConclusionsIncreased C-IMT, but within normal ranges, is associated independently of age with altered postprandial glucose profile, increased peripheral and hepatic insulin resistance, decreased b-cell function. C-IMT measurement should become a routine analysis even in younger subjects to predict the risk of cardio-metabolic disease.
