| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5947650 | Atherosclerosis | 2013 | 7 Pages |
ObjectiveThe benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteristics with plasma EPA and DHA levels.MethodsAPOE genotype was determined in this cross-sectional analysis of 2340 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Relative plasma phospholipid EPA and DHA levels, plasma lipids, and lipoprotein subclass particle sizes and concentrations were measured.ResultsSignificant gene-EPA interactions were found with HDL-C, and particle concentrations of large and total HDL (pinteraction = 0.0002, 0.006, and 0.007, respectively). The above lipid targets were positively associated with EPA in the E2 groups, whereas negative trends were observed among the E4 participants. Gene-DHA interactions were noted for small LDL particle concentrations alone (pinteraction = 0.01), where a positive trend was found among E4 but not E2 or E3 participants.ConclusionsThese results indicate a significant contribution of the APOE genotype to the EPA-lipid profile relationship; however, the results do not explain the differences in previous findings regarding LDL-C, triglycerides or total cholesterol. Future investigators examining the effects of EPA on HDL-C or lipoprotein characteristics may consider including APOE genotype in their analyses.
⺠A cross-sectional study among 2340 free-living and apparently healthy subjects. ⺠APOE genotype, plasma phospholipid EPA, DHA, and plasma lipid profiles were measured. ⺠APOE-EPA interactions were found with HDL-C, and large and total HDL particles. ⺠An APOE-DHA interaction was found for small LDL particle concentrations.
