APOA5 genotype influences the association between 25-hydroxyvitamin D and high density lipoprotein cholesterol

ObjectiveCirculating levels of 25-hydroxyvitamin D (25OHD) are positively associated with high density lipoprotein (HDL) cholesterol. We sought to replicate a previously reported interaction between APOA5 genotype and vitamin D, and to examine whether HDL-associated genetic loci modify the association between serum 25OHD and HDL cholesterol.MethodsWe examined whether 42 single nucleotide polymorphisms (SNPs) modify the association between serum 25OHD and HDL cholesterol in the 1958 British Birth cohort (aged 45 years, n = 4978).ResultsWe identified a borderline interaction between the SNP rs12272004 (near the APOA5) and serum 25OHD on HDL cholesterol (Pinteraction = 0.05). The interaction was particularly prominent among the samples collected during winter (Pinteraction = 0.001). None of the other loci showed an interaction with serum 25OHD concentrations on HDL cholesterol.ConclusionsOur study in 4978 British Whites provides further support that APOA5 genotype modifies the association between vitamin D metabolites and HDL cholesterol.