Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5947851 | Atherosclerosis | 2013 | 6 Pages |
â¢É2 Allele has a better response to moderate exercise.â¢É3 Allele has a better response to intense exercise.â¢Exercise was effective in attenuating postprandial lipemia in both É2 and É3 subjects.â¢Carriers of the É4 allele showed no attenuation of postprandial lipemia.
ObjectiveTo investigate the effect of aerobic exercise intensity on postprandial lipemia according to allelic variants of the apolipoprotein E gene.MethodsThree groups of 10 healthy men each were formed based genotyping of the APOE gene, rested or performed 500 Kcal tests in a random sequence separated by a minimum 48 h interval, as follows: (a) no exercise (control), (b) intense intermittent exercise, (c) moderate continuous exercise. Each test series was completed 30-min before ingestion of a high-fat meal (1 g fat/kg). Venous blood was collected before and at 1, 2, 3 and 4 h after the high-fat meal. Postprandial lipemia was assessed using the area under the curve approach as well as the kinetic profile of mean lipid variables. Statistical significance was adopted at P â¤Â 0.05 level.ResultsThe main results show that, in the moderate continuous exercise, total postprandial cholesterolemia was higher in É4 than in É2 carriers, whereas under intense intermittent exercise, total and LDL cholesterolemia were higher in É4 than in É2 and É3 carriers. There was no difference in the lipemic profile of the subjects across APOE genotypes at baseline.ConclusionModerate and intense exercise were effective in attenuating PPL in both É2 and É3 subjects, with É2 subjects being more susceptible to the lipid lowering effect of moderate training than É3 subjects. Carriers of the É4 allele, however, showed no attenuation of postprandial lipemia.