Article ID Journal Published Year Pages File Type
5948058 Atherosclerosis 2012 7 Pages PDF
Abstract
► Studying the role of PON1 in blood pressure (BP) regulation, using paraoxonase1 knockout (PON1KO) mice. ► Reduced BP observed in PON1KO is RAAS- and NO-independent. ► A direct, causal relation between PON1 and BP was observed. ► BP is inversely related to 5,6-EET which is regulated by PON1. ► Endothelial-derived hyperpolarization-like response is probably involved in the reduced BP in PON1KO mice.
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Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
Preview
Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid
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