Article ID Journal Published Year Pages File Type
5948086 Atherosclerosis 2012 4 Pages PDF
Abstract

ObjectivesTo address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts.MethodsWe genotyped for rs1333049, 4097 CHD-free participants including 3191 aged 65-86 years from the Three-City (3C) Study and 906 aged 59-71 years from the Vascular Aging Study (EVA). Plaque-free mean CCA-IMT and the presence of carotid plaques were assessed.ResultsIn multivariate analysis, each C allele copy of rs1333049 was associated with baseline carotid plaques (odds ratio (OR) = 1.24; 95% confidence interval (CI) = 1.13-1.36; p < 0.001) but not with baseline CCA-IMT (p = 0.19). Among the EVA participants, the C allele was associated with 4-year plaques progression (p = 0.04) but not with CCA-IMT progression.ConclusionThe chromosome 9p21 locus might influence CHD risk through carotid plaques development.

► We studied the link between rs1333049 and subclinical atherosclerosis in older adults. ► Carotid plaques and intima-media thickness were assessed by ultrasound examination. ► Common carotid intima-media thickness was precisely measured at a plaque-free site. ► The C allele of rs1333049 was associated with carotid plaques. ► Rs1333049 genotype was not associated with carotid intima-media thickness.

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Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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