Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5948835 | Atherosclerosis | 2012 | 5 Pages |
Abstract
Dietary Nrf2 activators increase expression of phase 2 protein genes in cells undergoing oxidative stress resulting in a lowering of oxidative stress. Oxidative stress promotes atherogenic processes through oxidizing low density lipoproteins and promotion of inflammation through activation of nuclear factor kappa B and activation of mitogen-activated protein kinases. Nrf2 activators by decreasing oxidative stress decrease the probability of developing atherosclerotic lesions.
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Authors
Bernhard H.J. Juurlink,