| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5948938 | Atherosclerosis | 2012 | 6 Pages |
BackgroundMacrocytosis, as a qualitative abnormality of erythrocytes, has not drawn attention as a prognostic indicator after PCI, while anemia, as a quantitative abnormality of erythrocytes, has been recognized as a predictor of adverse outcomes. The aim of this study was to perform prognostic risk stratification of patients after PCI based on the presence or absence of macrocytosis.MethodsThe clinical records of 941 consecutive patients who underwent PCI at a single institution were retrospectively reviewed. The prognostic implication of macrocytosis was evaluated by univariate and multivariate Cox's proportional hazard regression analysis.ResultsThere were 130 (13.8%) patients with macrocytosis. A significantly higher all-cause and cardiac mortality, as well as incidence of composite adverse events were observed in the Macrocytic group. Kaplan-Meier analysis also showed a significantly poorer overall survival in patients with macrocytosis. Even after exclusion of anemic patients, this tendency was still observed. Furthermore, macrocytosis was significantly and independently associated with adverse outcomes after PCI (aHR of cardiac death: 3.45, 95%CI: 1.22-9.80, PÂ =Â 0.019). Interestingly, fewer patients with macrocytosis were prescribed statins compared with those without it (33.8% vs. 47.1%, PÂ =Â 0.005).ConclusionsThe results of the study indicate that measuring mean corpuscular volume (MCV) as a qualitative index of erythrocytes might be helpful for a prognostic risk stratification of patients subjected to PCI.
⺠The aim of this study was to perform prognostic risk stratification of patients after PCI based on the presence or absence of macrocytosis. ⺠Significant higher incidence of adverse events, including all-cause and cardiac mortality, was observed in PCI patients with macrocytosis. ⺠Furthermore, macrocytosis was an independent predictor of cardiac death and composite of adverse cardiovascular events. ⺠Measuring mean corpuscular volume (MCV) might be helpful for a prognostic risk stratification of patients subjected to PCI.
