Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5949730 | Atherosclerosis | 2011 | 4 Pages |
ObjectiveGenetic variability in the NR1H3 gene (encoding LXRα) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. We sought to assess if these associations could be detected in adolescents.MethodsThirty-nine polymorphisms in NR1H3, ABCA1, APOE, CETP, PLTP and LPL were analysed in the HELENA study (n = 1144 European adolescents).ResultsThe minor alleles of rs11039155 in NR1H3, rs2575879 in ABCA1, rs708272, rs17231506 and rs5882 in CETP and rs328 in LPL were associated with higher serum HDL-C concentrations (p â¤Â 0.0012). The minor alleles of rs12221497 in NR1H3, rs1800978 in ABCA1 and the APOE É4 allele were associated with lower HDL-C concentrations (p â¤Â 0.01). The combined set of associated polymorphisms accounted for â¼6.6% of the variance in HDL-C.ConclusionWe report for the first time that polymorphisms in NR1H3 and its target genes ABCA1, APOE, CETP and LPL contribute to the genetic variance for HDL-C concentrations in adolescence.