| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5949796 | Atherosclerosis | 2011 | 9 Pages |
Abstract
XJP-1 inhibited LPS-induced cytotoxicity and inflammatory response. The mechanism underlying this protective effect might be related to the inhibition of MAPK and NF-κB signaling pathway activation, suggesting the potential inhibition of the atherosclerotic process by suppressing the expression of chemoattractant molecules and monocyte adhesion. XJP-1 also has an effect in improving endothelin-1 through activating bradykinin B2 receptor. These findings indicated that XJP-1 is potentially a novel therapeutic candidate for the treatment of atherosclerosis.
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Authors
Rong Fu, Zhen Chen, Qiujuan Wang, Qinglong Guo, Jinyi Xu, Xiaoming Wu,