| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5949956 | Atherosclerosis | 2011 | 7 Pages |
Abstract
Our results indicate that EL and EL-generated LPC, except of LPC 18:2, promote endothelial IL-8 synthesis, with different efficacy and kinetics, related to acyl-chain length and degree of saturation. Accordingly, due to its capacity to modulate the availability of the pro-inflammatory and pro-adhesive chemokine IL-8, EL should be considered an important player in the development of atherosclerosis.
Keywords
MIP-22-arachidonoyl-glycerolPKCIL-8NEFApKaLPC2-AGGFXERKGF109203XFFAHDLLysophosphatidylcholine (LPC)p38-mitogen-activated protein kinaseBSAhigh-density lipoproteinNFκBp38-MAPKAtherosclerosisAdenovirusbovine serum albuminArachidonic acidFree fatty acidsNonesterified fatty acidsHAECEndothelial cellshuman aortic endothelial cellsnuclear factor kappa BLysophosphatidylcholineEndothelial lipaseprotein kinase AProtein kinase Cextracellular regulated kinase
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Authors
Monika Riederer, Margarete Lechleitner, Andelko Hrzenjak, Harald Koefeler, Gernot Desoye, Akos Heinemann, Saša Frank,