| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5950127 | Atherosclerosis | 2011 | 7 Pages |
Abstract
In ACS, MRP8 and MRP8/14 complex are specific ligands of TLR4, which induce the release of TNFα and probably other pro-inflammatory agents from monocytes. This specific MRP8/14-dependent pathway with striking similarities to sepsis increasing expression of TLR4 in thrombi appears to be involved in the pathogenesis of coronary occlusion and may represent a novel therapeutic target in ACS.
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Authors
Keiko Yonekawa, Michel Neidhart, Lukas A. Altwegg, Christophe A. Wyss, Roberto Corti, Thomas Vogl, Mariam Grigorian, Steffen Gay, Thomas F. Lüscher, Willibald Maier,