Article ID Journal Published Year Pages File Type
5950786 Atherosclerosis 2011 9 Pages PDF
Abstract
These observations indicate that calpain promotes ABCG1 degradation by cleaving cell surface-resident ABCG1, and consequently reduces the expression and cholesterol efflux function of ABCG1. Inhibition of ABCG1 cleavage by calpain could be a novel approach to suppress the progression of atherosclerosis.
Keywords
Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
Preview
Calpain-mediated cleavage negatively regulates the expression level of ABCG1
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