Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse-a histopathology-based study

This study indicated that the initial body weight and virus infection dose are two factors affecting the onset of viral myocarditis in C57BL/6 mice. Accordingly, initial body weight of 18-20 g and an inoculation dose of 100,000 TCID50/ml×0.3 ml CVB3 might be an optimal choice to induce acute viral myocarditis in C57BL/6 mice.