Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
59526 | Chinese Journal of Catalysis | 2012 | 5 Pages |
A sulfonated carbon material was shown to be a highly efficient, eco-friendly, and recyclable solid acid catalyst for the Biginelli reaction of β-ketoester, aldehyde, and urea or thiourea under solvent-free conditions. It gave 3,4-dihydropyrimidin-2(1H)-ones and -thiones in good to excellent yields. This method has the advantages of a simple procedure with easy work-up, short reaction time, and high yields. The catalyst can be recycled after a simple work-up and was reused four times without substantial reduction in activity.
Graphical abstractA very simple and efficient method for the synthesis of dihydropyrimidin-2(1H)-ones and -thiones by the Biginelli reaction of β-ketoesters, aldehydes, and urea or thiourea with sulfonated carbon as a recyclable solid acid catalyst under solvent-free conditions is described.Figure optionsDownload full-size imageDownload as PowerPoint slide