Article ID Journal Published Year Pages File Type
59526 Chinese Journal of Catalysis 2012 5 Pages PDF
Abstract

A sulfonated carbon material was shown to be a highly efficient, eco-friendly, and recyclable solid acid catalyst for the Biginelli reaction of β-ketoester, aldehyde, and urea or thiourea under solvent-free conditions. It gave 3,4-dihydropyrimidin-2(1H)-ones and -thiones in good to excellent yields. This method has the advantages of a simple procedure with easy work-up, short reaction time, and high yields. The catalyst can be recycled after a simple work-up and was reused four times without substantial reduction in activity.

Graphical abstractA very simple and efficient method for the synthesis of dihydropyrimidin-2(1H)-ones and -thiones by the Biginelli reaction of β-ketoesters, aldehydes, and urea or thiourea with sulfonated carbon as a recyclable solid acid catalyst under solvent-free conditions is described.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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