Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5953703 | Chest | 2015 | 8 Pages |
Abstract
The results show telomere shortening across all ILD diagnoses. The difference in TL between the FIP-TERT and FIP-SFTP groups indicates the distinction between acquired and innate telomere shortening. Short TL in the IPF and FIP-no mutation groups is indicative of an innate telomere-biology defect, while a stress-induced, acquired telomere shortening might be the underlying process for the other ILD diagnoses.
Keywords
CTD-ILDCOPIPFfamilial interstitial pneumoniaFIPIIPSFTPT/SILDInterstitial lung diseaseconnective tissue disease-associated interstitial lung diseaseTERTTelomerase reverse transcriptaseTelomere lengthidiopathic pulmonary fibrosispolymerase chain reactionPCRSurfactant proteinIdiopathic interstitial pneumoniaCryptogenic organizing pneumoniaHypersensitivity pneumonitis
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Authors
Reinier MSc, Coline H.M. PhD, Karin M. BSc, Joanne J. BSc, Pieter MD, PhD, Matthijs F.M. MD, PhD, Jan C. MD, PhD,