Splenectomy exacerbates atrial inflammatory fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats: Possible role of spleen-derived interleukin-10

Article ID	Journal	Published Year	Pages	File Type
5959288	Heart Rhythm	2016	24 Pages	PDF

Abstract

The study results suggest that SPX exacerbates AAC-induced inflammatory atrial fibrosis and increases vulnerability to AF after 4 weeks, likely because of depletion of spleen-derived IL-10.

Keywords

TNF Bcl SPX MCP-1 AAC smooth muscle actin Splenectomy inflammation interleukin Interleukin-10 Pressure overload abdominal aortic constriction cluster of differentiation SMA Left atrium Right atrium Spleen tibia length basic cycle length tumor necrosis factor Fibrosis Atrial fibrillation IACT body weight Heart weight monocyte chemoattractant protein-1

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Preview

Splenectomy exacerbates atrial inflammatory fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats: Possible role of spleen-derived interleukin-10

Authors

Hidekazu MD, Naohiko MD, PhD, Koro MD, PhD, Akira MD, Shotaro MD, Kohei MD, Osamu MD, PhD, Tetsuji MD, PhD, Yasushi MD, PhD, Tetsunori MD, PhD,