Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5959483 | Heart Rhythm | 2016 | 10 Pages |
Abstract
JPH-2 is more than a “dyad glue”: it can modulate Cai handling and ion channel function in the dyad region. Downregulation of JPH-2, BIN-1, and Cav1.2 plays a deterministic role in PVC-CM. Dissecting the hierarchical relationship among the three is necessary for the design of therapeutic interventions to prevent the progression of PVC-CM.
Keywords
NCXICaLCa-induced Ca releasejunctophilin-2Na/Ca exchangerWGAImmunoprecipitateIKST tubulesslow delayed rectifier currentRyR2JSRPremature ventricular contractionsconLeft ventricularExcitation-contraction couplingtransverse tubuleDyadSarcoplasmic reticulumSuperJunctional sarcoplasmic reticulumAntibodyCardiomyopathycalsequestrin 2CICRControlWheat germ agglutininRyanodine receptor 2
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Min PhD, Mei PhD, Maureen BS, Yuhong PhD, Alex MD, Ravi C. PhD, Jose F. MD, FHRS, FAHA, Gea-Ny PhD, FAHA,