| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5959483 | Heart Rhythm | 2016 | 10 Pages |
Abstract
JPH-2 is more than a “dyad glue”: it can modulate Cai handling and ion channel function in the dyad region. Downregulation of JPH-2, BIN-1, and Cav1.2 plays a deterministic role in PVC-CM. Dissecting the hierarchical relationship among the three is necessary for the design of therapeutic interventions to prevent the progression of PVC-CM.
Keywords
NCXICaLCa-induced Ca releasejunctophilin-2Na/Ca exchangerWGAImmunoprecipitateIKST tubulesslow delayed rectifier currentRyR2JSRPremature ventricular contractionsconLeft ventricularExcitation-contraction couplingtransverse tubuleDyadSarcoplasmic reticulumSuperJunctional sarcoplasmic reticulumAntibodyCardiomyopathycalsequestrin 2CICRControlWheat germ agglutininRyanodine receptor 2
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Authors
Min PhD, Mei PhD, Maureen BS, Yuhong PhD, Alex MD, Ravi C. PhD, Jose F. MD, FHRS, FAHA, Gea-Ny PhD, FAHA,