Enhanced fast-inactivated state stability of cardiac sodium channels by a novel voltage sensor SCN5A mutation, R1632C, as a cause of atypical Brugada syndrome

Article ID	Journal	Published Year	Pages	File Type
5959542	Heart Rhythm	2015	9 Pages	PDF

Abstract

R1632C showed a loss of function of INa by an enhanced fast-inactivated state stability because of a pronounced impairment of recovery from fast inactivation, which may explain the phenotypic manifestation observed in our patient.

Keywords

BRS cDNA Complementary DNA Atrial tachycardia Brugada syndrome Atrial fibrillation

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

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Enhanced fast-inactivated state stability of cardiac sodium channels by a novel voltage sensor SCN5A mutation, R1632C, as a cause of atypical Brugada syndrome

Authors

Tadashi MD, PhD, Yoshiaki MD, PhD, Akihiro MD, PhD, Masaki MD, Takafumi MD, PhD, Masahiko MD, PhD,