| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5959700 | Heart Rhythm | 2015 | 11 Pages |
Abstract
SK channels are widely distributed in atrial and ventricular cardiomyocytes and contribute to atrial repolarization. Inhibition by NS8593 terminates pacing-induced AF of short duration and decreases AF duration and vulnerability without affecting ventricular conduction and repolarization. Thus, inhibition by NS8593 demonstrates clear atrial antiarrhythmic properties in healthy horses.
Keywords
APDdV/dtmaxSK3SK1RAASK2AERPt½RT-PCRcDNAComplementary DNAHorseEquineAtrial electrophysiologyProgrammed electrical stimulationanalysis of varianceANOVAIntravenousAntiarrhythmic drugsatrial effective refractory periodright ventricular free wallright atrial appendageSinus rhythmHeart rateAtrial fibrillationAction potential durationreverse transcription polymerase chain reactionPacing
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Authors
Maria Mathilde DVM, FHRS, Eva Zander DVM, Steen MD, PhD, Helena DVM, Mette DVM, Kirstine Færgemand DVM, Ulrik Svane PhD, Jonas Goldin PhD, FHRS, Morten PhD, FHRS, Rikke DVM, PhD, Thomas PhD, FHRS,