| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5959858 | Heart Rhythm | 2015 | 22 Pages |
Abstract
Our study supports the use of genetic testing to identify individuals at risk of SCD to undertake prophylactic interventions. We also show that the pathogenic mechanisms of p.G357S_RyR2 appear to depend on β-adrenergic stimulation.
Keywords
SOICRCPVTETTpKaRyR2CVASCDEC50cAMPCyclic adenosine monophosphateVentricular arrhythmiaArrhythmiasGenetic testingelectrocardiogramECGCatecholaminergic polymorphic ventricular tachycardiaexercise treadmill testICDSudden cardiac deathwild typehalf maximal effective concentrationprotein kinase AImplantable cardioverter-defibrillator
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Authors
Fernando PhD, MD, Cristina MSc, Carmelo BD, Oscar PhD, Pedro PhD, Fabiana S. PhD, Anna MSc, Paola MD, Catarina PhD, Pablo M. PhD, MD, Josep PhD, MD, Guillermo J. PhD, Ramon PhD, MD,