| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5959983 | Heart Rhythm | 2015 | 12 Pages |
Abstract
These data suggest that ablation of SAP97 in the mouse heart mainly alters potassium channel function. Based on the important role of SAP97 in regulating the QT interval, DLG1 may be a susceptibility gene to be investigated in patients with congenital long QT syndrome.
Keywords
RT-PCRSAP97ISSIK1QTcAPDINaelectrocardiogramECGITOsodium currentTransient outward potassium currentInward rectifier potassium currentcorrected QT intervalIKurAction potential durationTissue-specific knockoutreverse transcriptase–polymerase chain reactionaction potentialSodium ChannelPotassium channel
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Authors
Ludovic PhD, Jean-Sébastien PhD, Diana MSc, Stephan PhD, Nathalie PhD, Maria BSc, Doron PhD, Elise PhD, Stéphane N. MD, PhD, Hugues MD, PhD,