Clinical and serum-based markers are associated with death within 1 year of de novo implant in primary prevention ICD recipients

Article ID	Journal	Published Year	Pages	File Type
5960407	Heart Rhythm	2015	7 Pages	PDF

Abstract

Individuals with more comorbidities and elevation of specific serum biomarkers were at increased risk of all-cause mortality despite being deemed as having a reasonable 1-year life expectancy. A simple risk score composed of readily available clinical data and serum biomarkers may better identify patients at high risk of early mortality and improve patient selection and counseling for primary prevention ICD therapy.

Keywords

EGFR ICD shock Tumor necrosis factor receptor II cTNT cTnI IL-6 CK-MB NYHA BNP IL-10 AUC New York Heart Association Interleukin 10 interleukin 6 cardiac troponin T tumor necrosis factor α ICD LLOD Coefficient of Variation confidence interval TNF-α cardiac troponin I lower limit of detection Sudden cardiac death Early mortality area under the curve estimated glomerular filtration rate C-reactive protein CRP brain natriuretic peptide Primary prevention Implantable cardioverter-defibrillator creatine kinase MB

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Clinical and serum-based markers are associated with death within 1 year of de novo implant in primary prevention ICD recipients

Authors

Yiyi PhD, Eliseo MD, DrPH, Elena MD, PhD, Darshan MD, PhD, Barbara RN, Sanaz BA, Fleur V.Y. MD, Zayd MD, PhD, FHRS, Timm MD, PhD, FHRS, Kenneth A. MD, FHRS, Joseph E. MD, FHRS, Gordon F. MD, FHRS, Alan MD, FHRS,