| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5960614 | Heart Rhythm | 2014 | 9 Pages |
Abstract
PVCs increase dispersion of action potential configuration/duration, a risk factor for sudden cardiac death, because of the heterogeneous reduction in Ito, IK1, and ICaL. The excitation-contraction coupling is impaired because of the decrease in ICaL and Cav1.2 misalignment with respect to ryanodine receptor 2.
Keywords
slow delayed rectifier currentIKrICaLAPDWGAIK1junctophilin-2E-CIKST-tubulesintracellular Ca2+ concentrationsSCDRyR2[Ca2+]iPremature ventricular contractionITOconElectrical remodelingLeft ventricularexcitation-contractionExcitation-contraction couplingTransient outward currentinward rectifier currentSarcoplasmic reticulumTransverse tubulesAction potential durationSudden cardiac deathaction potentialPVCCardiomyopathyControlWheat germ agglutininRyanodine receptor 2
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Authors
Yuhong PhD, Jose M. PhD, Karoly MD, PhD, FHRS, Alex MD, Min PhD, Mei PhD, Gea-Ny PhD, FAHA, Jose F. MD, FHRS,