KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia

Article ID	Journal	Published Year	Pages	File Type
5960785	Heart Rhythm	2014	10 Pages	PDF

Abstract

R67Q-Kir2.1 is associated with an adrenergic-dependent clinical and cellular phenotype with rectification abnormality enhanced by increased calcium. These findings are a significant advancement of our knowledge and understanding of the phenotype-genotype relationship of arrhythmia syndromes related to KCNJ2 mutations.

Keywords

PBS rectification index OSH KCNJ2 Andersen-Tawil syndrome IK1 CASQ2 CPVT ATS Kir2.1 RyR2 Inherited arrhythmia Ventricular arrhythmia electrocardiogram ECG Catecholaminergic polymorphic ventricular tachycardia inward rectifier current phosphate buffer solution Ryanodine receptor

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KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia

Authors

Matthew M. MD, Ravi PhD, Kate M. MS, Sara BS, Nicholas BS, Kathleen R. MD, Craig T. MD, PhD, Jonathan C. MD, Lee L. MD, FHRS,