Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5960900 | Heart Rhythm | 2014 | 9 Pages |
Abstract
We have identified a distal truncated SCN5A mutant associated with gain- and loss-of-function effects, leading to sick sinus syndrome and atrial arrhythmias. A constitutively higher susceptibility to arrhythmias of atrial tissues and genetic variability could explain the complex phenotype observed in this family.
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Authors
Azza MD, PhD, Jérôme PhD, Sabine PhD, Estelle MD, PhD, Isabelle MD, Françoise MD, Stéphane MD, PhD, Isabelle PhD, Alain PhD, Nathalie PhD, Pascale PharmD, PhD,