Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5961140 | Heart Rhythm | 2013 | 8 Pages |
Abstract
The electronic expression of IK1 is a simple and robust method to significantly improve the physiological behavior of the AP and electrical profile of h-iPSC-derived cardiac myocytes. Increased stability enables the use of this preparation for a controlled quantitative analysis of AP parameters, for example, drug responsiveness, genetic disorders, and dynamic behavior restitution profiles.
Keywords
APDdV/dtmaxIK1EADICAIPSCDADINaArrhythmiaearly afterdepolarizationITOPacemaker currentsodium currentTransient outward potassium currentInward rectifier potassium currentcalcium currentRepolarizationStem cellhuman-induced pluripotent stem cellInduced pluripotent stem cellTimothy syndromeHeartAction potential durationaction potentialdelayed afterdepolarizationPotassium channel
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Authors
Glenna C.L. PhD, Aaron D. MS, Agnieszka PhD, Thomas R. MD, PhD, Emmanuel S. PhD, Qinlian PhD, Michael J. PhD, Randall L. PhD,