Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization

Article ID	Journal	Published Year	Pages	File Type
5961306	Heart Rhythm	2013	9 Pages	PDF

Abstract

Amiloride regulates IKs and APs with transmural differences and reduces arrhythmogenicity through the modulation of KCNQ1 splicing. We suggested that the modulation of KCNQ1 splicing may help prevent arrhythmia.

Keywords

Transmural dispersion of repolarization RT-PCR TDR KCNQ1 IKS ICaL pKa EPI EAD APD MID amiloride ECG electrocardiogram endo endocardial early afterdepolarization Epicardial ISO isoproterenol Alternative splicing L-type calcium current cycle length Action potential duration ORD Reverse transcriptase-polymerase chain reaction action potential protein kinase A

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

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Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization

Authors

Hsiang-Chun MD, Msc, Yoram PhD, FHRS, Po-Yuan PhD, Sheng-Hsiung MD, Jan-Gowth MD, Jianmin PhD,