Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5961666 | Heart Rhythm | 2010 | 8 Pages |
Abstract
Structure-based drug design can be applied to the development of pharmacophores that act directly on Cx43. Small molecules containing these pharmacophores can serve as tools to determine the role of gap junction regulation in the control of cardiac rhythm. Future studies will determine whether these compounds can function as pharmacologic agents for the treatment of a selected subset of cardiac arrhythmias.
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Authors
Vandana PhD, Bjarne Due PhD, Wanda BS, Xianming PhD, Eliana BS, Steven M. PhD, Mario MD, PhD, FHRS,