| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5961878 | Heart Rhythm | 2008 | 9 Pages |
Abstract
In an intact rabbit heart model of LQT2 and LQT3 as well as in a computer model of the rabbit cardiac myocyte, inhibition of NCX is effective in preventing TdP due to a suppression of EADs, a reversion of action potential prolongation, and a reduction of dispersion of repolarization. Our observations suggest a therapeutic benefit of selective NCX inhibition in LQTS.
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Authors
Peter MD, Christian MD, Martin PhD, Gerrit MS, Toshio PhD, Akemichi PhD, Nani PhD, Günter MD, FESC, FACC, FHRS, Denis PhD, CBE, FRS, FRCP (Hon), Lars MD,